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Structural and functional studies of membranes and enzymes acting at membrane interfaces

Date: 1.1.1996-31.12.1997
Code: 26601
Department: Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), Dept. of Biochemistry and Pharmacy
Address: BioCity, Artillerig. 6, FIN-20520 Åbo
Phone +358-2-2154 689
Fax +358-2-2154 745
E-mail j.peter.slotte@abo.fi
Project leader: FD J. Peter Slotte, överassistent, tf. professor (1.1.1996-31.12.1997)
Researchers: FM Robert Kronqvist (1.1.1996-31.12.1997)
Type of research: 0 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 100 %
Finnish funding organizations: Finlands Akademi () FIM 480000
Man months: Totally: 36 months
Partners: Robert Bittman, New York, NY; Konrad Sandhoff, Bonn, Tyskland
Keywords: celler, lipider, solut, lipidit, lipidsamverkan, modellmembraner, ytfilmer, kolesterol, fosfolipider, enzymer, fosfolipaser, sfingomyelinas, cyklodextriner, cholesterol, phospholipids, membranes, monolayer membranes, domain formation, lipid interaction, cholesterol oxidase, sphingomyelinase,

The purpose of this project is to study lateral domain formation in model membrane systems, and to evaluate the effect of lipid structure on domain formation.Other goals are to study the function of enzymes acting at water/lipid interfaces (e.g. cholesterol oxidase, sphingomyelinase) and examine how the quality of the interface determines catalytic efficiency of enzymes.We also want to study the effect of domain formation on enzyme function at membraneous interfaces.


11.3.1996 / 4.3.1998