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No 13 / 55

Molecular characterization of rhabdovirus 903/87 isolated from brown trout in Finland, and induction of cytokines in fish cells as a response to rhabdovirus infection (Karakterisering av fiskvirus; Projekt 9115)

Date: 1.1.1995-31.12.1998
Code: 2648
Department: Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), The Institute of Parasitology
Address: BioCity, Artillerigatan 6, FIN-20520 Åbo
Phone +358-2-2154 604
Fax +358-2-2154 748
E-mail hbjorklu@abo.fi
Project leader: FD Harry Björklund, forskningsassistent (1.1.1995-31.12.1998)
Researchers: FM Tove Johansson (15.2.1995-)
Type of research: 0 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 100 %
Finnish funding organizations: Finlands Akademi () FIM
Man months: Totally: 18 months
Partners: Dr.Gael Kurath, National Biological Service, Seattle, USA
Contacts: Dr.Gael Kurath, molekulärbiologi hos rhabovirus, Seattle USA; Doc.John Eriksson, cellulära mekanismer i apoptos, Biotenikcentret, BioCity; Dr.Niels Lorenzen, virusimmunologi, Århus, Danmark
Keywords: fisk, virus, kalat, virukset, fisk, rhabdovirus, kloning, sekvensering, virus-värdecellinteraktioner, fish, rhabdovirus, cloning, sequencing, virus-host cell interactions,

The objectives of the research are to clone, sequence and characterize parts of the genome of a new rhabdovirus isolated from fish in Finland, and to study the pathogenicity of rhabdoviruses in fish cells.The aim of the pathogenicity studies are to elucidate virus-host cell interactions using several different fish rhabdoviruses and several permanent fish cell lines.We are studying rhabdovirus induced apoptosis and induction of cytokine-like substances in fish cells as a response to rhabdovirus infections.The research metods include cell culture, and different techniques in molecular biology and cell biology.


15.2.1996 / 29.2.1996