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No 31 / 55

Neuropeptide FF and pain regulation (Neuropeptid FF)

Date: 1.1.1995-31.12.2003
Code: 26712
Department: Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), Dept. of Biology
Address: BioCity, Artillerigatan 6, FIN-20520 Åbo
Phone +358-2-2154 265
Fax +358-2-2154 748
E-mail ppanula@abo.fi
Project leader: MKD Pertti Panula, professor (1.1.1993-31.12.2003)
Researchers: FK Katja Kuokkanen (1.8.1996-)
MK Maija-Liisa Nieminen (-)
Type of research: 0 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 80 %
- applied research 20 %
Finnish funding organizations: Stiftelsen för alkoholforskning, Helsingfors () FIM 200000
Sigrid Juselius Stiftelsen () FIM
Borg's Fond () FIM
Man months: 19 months in 1997; Totally: 171 months
Keywords: smärta, hjärnan, centrala nervsystemet, blodtryck, kipu, aivot, keskushermosto, verenpaino, hjärnan, smärta, opiater, receptorer, brain, pain, opiate, receptors, spinal cord,

Neuropeptide FF (NPFF) is a newly discovered and cloned neuropeptide, which is expressed almost exclusively in the central nervous system.It is involved in pain transmission, regulation of automatic functions including blood pressure and hormone secretion.Depending on the site of administration, NPFF either attenuates or potentiates the analgesic effect of morphine.In previous studies we have characterized the molecular forms, distribution and pathways of NPFF-like peptides in the brain.Current studies are aimed at identification of brain areas and cell types which express NPFF, and regulation of the NPFF gene in rat and human nervous system.Characterization of the signal transduction mechanisms and cloning of the receptor(s) are also important goals, because NPFF may offer new possibilities to treat pain and blood pressure

Publication(s)

15.2.1996 / 9.4.1997