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No 43 / 55

Imaging of biological signal transduction processes

Date: 3.12.1997-31.12.2000
Code: 3973
Department: Åbo Akademi University / Faculty of Mathematics and Natural Sciences (MNF), Dept. of Biochemistry and Pharmacy
Address: BioCity, Artillerig. 6A/P.O.Box 66, FIN-20521 Åbo
Phone +358-2-2154 014
Fax +358-2-2154 745
E-mail Johnson@abo.fi
Project leader: Ph.D., Docent Mark Stuart Johnson, professor (13.12.1997-31.12.1999)
Researchers: FD, docent John Eriksson (3.12.1997-31.12.2000)
(-)
FD, professor Pertti Panula (3.12.1997-31.12.2000)
FL Rolf Sara (3.12.1997-31.12.2000)
Type of research: 2 (0=Within duty, 1=Ordered research, 2=Co-operation)
- basic research 40 %
- applied research 20 %
- developmental work 40 %
Finnish funding organizations: Finlands akademi, Helsingfors (Cell Biology Program of Academy of Finland) FIM 6000000
Foreign funding organizations: Erna och Victor Hasselblads Stiftelse i Sverige ()
Man months: Totally: 84 months
Contacts: TEKES: Bioinformational attack on superfamily modelling and drug discovery
Keywords: biokemi, biokemia, visualisering, celler, vävnader, molekyler, visualization, cells, tissues, molecules,

The aim of this project is to enable visualization cellular signaling on all levels of structural organization, including molecular dynamics and interactions of signaling molecules, signaling events on the cell surface and in the cytoplasm as well as signaling processes in intact tissues.We attempt to use state-of-the-art devices for collection of data from all these organizational levels.Furthermore,we are going to employ computerized analytical imaging applications that have not been used in the context of biological imaging before.This is necessitated by the complexity of detail of such images.To cope with them, and to maximally exploit their use, requires new techniques that extend beyond the scope of display modes and the software that is presently available.The research consortium represents expertise in molecular structures and modelling, cell signaling mechanisms,neuroanatomy and histochemistry, and applications of computer systems in biological imaging.

Publication(s)

11.3.1996 / 12.6.1998